张晓溪，男，博士，副研究员，广西糖尿病系统医学重点实验室核心成员，广西免疫学重点学科学术带头人，桂林医学院基础医学研究所科研人员。长期从事糖尿病相关代谢与免疫交互作用及调节机制研究，主要关注自身免疫性糖尿病的免疫调节机制和信号通路研究及药物研发。其科研项目“不同人胰淀素聚集程度通过TLR4/MyD88介导调节性T细胞免疫机制”获国家自然科学基金资助；主持1项并参与3项国家级项目，主持2项省部级项目；有38篇论文发表在国内外著名医学刊物上，如：Immunol Res.、Cytokine、Front Endocrinol、Diabetes Care等等，其中以第一作者或通讯作者发表SCI论文11篇。

代表性研究成果和学术奖励情况

1.Yang L, Yang J, Liang X, Huang W,Zhang X, Li R. Uncovering antiobesity-related hypertension targets and mechanisms of metformin, an antidiabetic medication. Bioengineered. 2021 Dec;12(1):4757-4767.

2.Li R, Qin X, Liang X, Liu M,Zhang X. Lipidomic characteristics and clinical findings of epileptic patients treated with valproic acid. J Cell Mol Med. 2019 Sep;23(9):6017-6023.

3.Endocrinological characterization of pancreatic ducts in HFD and HGD fed mice.Wenjun Huang, Lianxiu Su,Xiaoxi Zhang, Xiaoxiao Xu, Rong Li.J Cell Biochem. 2019Sep;120(9):16153-159

4.Xiaoxi Zhang^#, Yongchao Qiao^#, Wan Li, Xia Zou, Yincing Chen, Jian Shen, Qinyuan Liao, Qiujin Zhang, Lan He, Hailu Zhao*. Human amylin induces CD4+Foxp3+ regulatory T cells in the protection from autoimmune diabetes.Immunol Res. 2018 Feb;66(1):179-186.

5.Xiaoxi Zhang, Yanhong Pan, Yanmei Huang, Hailu Zhao*. Neuroendocrine hormone amylin in diabetes. World J Diabetes. 2016 May 10;7(9):189-97.

6.Xia Zou^#,Xiaoxi Zhang^#, Xinyu Liu, Rong Li, Min Wang, Weijie Wu, Yi Sui, Hailu Zhao*. Renal kallikrein activation and renoprotection after dual blockade of renin-angiotensin system in diet-induced diabetic nephropathy. J Diabetes Res. 2015;2015:310645.

7.Chen Yinling^#，Yongchao Qiao^#, Yanhong Pan, Yan Xu, Yongcheng Huang, Yinghui Wang, Lijun Geng, Hailu Zhao,Xiaoxi Zhang*. Correlation between serum interleukin-6 level and type 1 diabetes mellitus: A systematic review and meta-analysis. Cytokine. 2017 Jun;94:14-20.

8.Chen Yinling^#，Yongchao Qiao^#, Xinnan Song, Wei Ling, Hailu Zhao,Xiaoxi Zhang*.Emotional exhaustion-induced latent autoimmune diabetes in adults in a young lady: A CARE-compliant case report. Medicine (Baltimore). 2017 May;96(20):e6915.

9.Chen Yinling, Yongcheng Huang, Yongchao Qiao, Wei Ling, Yanhong Pan, Lijun Geng, Jianlong Xiao,Xiaoxi Zhang*, Hailu Zhao*.Climates on incidence of childhood type 1 diabetes mellitus in 72 countries. Sci Rep. 2017 Oct 9;7(1):12810.

10.Chen Yinling^#，Yongchao Qiao^#, Yan Xu, Wei Ling, Yanhong Pan, Yongcheng Huang, Lijun Geng, Hailu Zhao,Xiaoxi Zhang*. Serum TNF-α concentrations in type 2 diabetes mellitus patients and diabetic nephropathy patients: A systematic review and meta-analysis. Immunol Lett. 2017 Apr 13;186:52-58. doi: 10.1016/j.imlet.2017.04.003.

11.Xiaoxi Zhang^#, Haixue Zheng^#, Mingjun Xu, Yu Zhou, Xiangping Li, Fan Yang, Qingyou Liu*, Deshun Shi*.Evaluation of a combinatorial RNAi Lentivirus vector targeting foot-and-mouth disease virus both in vitro and in vivo.Mol Med Rep.2015 Nov;12(5):6672-8.

12.Xiaoxi Zhang^#, Qingyou Liu^#, Chan Luo, Yanfei Deng, Kuiqing Cui, Deshun Shi*.Identification and characterization of buffalo 7SK and U6 pol III promoter for expression of short hairpin RNAs. Int J Mol Sci. 2014.15(2):2596-607

13. Liuxue Yang^#, Jianfei Song^#,Xiaoxi Zhang^#, Liuping Xiao, Xueping Hu, Haidong Pan, Linyuan Qin, Hongbo Liu, Bo Ge, Tianpeng Zheng*. Association of Serum Angiopoietin-Like Protein 8 With Albuminuria in Type 2 Diabetic Patients: Results From the GDMD Study in China. Front Endocrinol (Lausanne). 2018 Jul 18;9:414.

14.Tianpeng Zheng*, Linyuan Qin, Bo Chen, Xueping Hu,Xiaoxi Zhang, Yihong Liu, Hongbo Liu, Shenghua Qin, Gang Li, Qinghua Li .Association of Plasma DPP4 Activity With Mild Cognitive Impairment in Elderly Patients With Type 2 Diabetes: Results From the GDMD Study in China. Diabetes Care. 2016 Jul 1. pii: dc160316.

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